Centre for MACH - MultidisciplinAry ResearCh in Health Science

Directors' Profile

Infectious Diseases

The Infectious Diseases Unit aims to prevent, diagnose and treat the broad spectrum of infectious problems recognized in modern medicine. Its director, Professor Andrea Gori, dedicated his research career to mycobacterial infections, HIV and multidrug-resistant organisms involved in hospital-acquired infections.
The Infectious Diseases Unit is an international landmark and leading centre for emerging infectious diseases and, by its location inside the hospital, makes the Institute a unique model of collaboration between researchers, healthcare professionals, patients and community representatives. The Infectious Diseases Unit carries out translational research in collaboration with research and healthcare centres worldwide, moreover, develops and participates in clinical trials to evaluate novel therapeutic strategies.
The Infectious Disease Unit is also responsible for developing strategies oriented to a wiser use of antimicrobial drugs, and recommendations aimed to reduce the incidence of hospital-acquired infections, particularly those caused by multi-drug-resistant organisms.

Andrea Gori

Graduated from Medical School at the University of Milan.
Full Professor of Infectious Diseases at the University of Milan and Head of the Infectious Diseases Unit at Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan.

Infectious Diseases

The Infectious Diseases Unit will extend its clinical research on HIV, HCV coinfection, non-AIDS cancers, immune-markers of clinical progression and issues related to special populations through cohort studies.
Its Director, Professor Antonella d’Arminio Monforte, has been mainly involved in clinical research on HIV, in particular on diagnosis and prognosis of HIV-related opportunistic diseases, vertical transmission of HIV and HBV, diagnosis of HIV related CNS diseases, AIDS and non- AIDS cancers, clinical trials and observational studies on antiretrovirals (ART), resistance to ART and clinical implications, presentation and prognosis of HIV among women, and the role of inflammation, immuneactivation and intestinal microbioma in the disruption of the immune function and in progression of HIV.
She is President of the ICONA Cohort, a multicenter cohort, involving 52 clinical centers across Italy and recruiting HIV positive patients naïve from antiretrovirals. The cohort is one of the most important worldwide, now accounting for more than 16.000 HIV-positive individuals. ICONA Cohort stands apart as the only cohort capable of supplying reliable data on the impact of initial treatments on epidemiological, clinical, biological, and behavioral parameters. She is also the director of the post-graduated school of infectious and tropical diseases of the University of Milan and member of the board of the PhD School on clinical research at the university of Milan.

Antonella d’Arminio Monforte

Graduated from Medical School at the University of Milan. Full Professor of Infectious Diseases at the University of Milan and Director of the Clinic of Infectious Diseases of the Department of Health Sciences at the ASST Santi Paolo e Carlo, in Milan.

Immunology and Immunopathology

The Immunology and Immunopathology unit (IIU) analyzes the pathogenetic basis of communicable and non-communicable diseases in humans.
The IIU is coordinated by Professor Mario (Mago) Clerici, M.D., who received his training at the NIH in Bethesda, USA and has focused his research activity on the immunopathogenesis of infectious diseases, autoimmune conditions and chronic neurologic diseases.
The IIU will perform state-of-the-art translational research on these pathologies and, in collaboration with the IRCCS Ospedale Maggiore and the most prestigious research organizations worldwide, will expand its research horizons to include the immunology of organ transplantation, metabolic and degenerative conditions and inherited coagulopathies.
The IIU will collaborate with the PhD School of Translational Medicine of the University of Milan in purveying excellence in research and will become a pivotal player in the international scenario in organizing and performing clinical trials and the development of novel vaccinal and therapeutic approaches to human diseases.

Mario (Mago) Clerici

Graduated from Medical School at the University of Milan. Directed the PhD School in Molecular and Translational Medicine at the University of Milan.
Full Professor of Immunology and Head of the Department of Pathophysiology and Transplantation at the University of Milano.

Microbiology and Virology

The Microbiology and Virology Unit focuses its work on the research of mechanistic causes of antimicrobial resistance, especially viruses, bacteria and fungi. Particular attention is dedicated to the infections in the immunocompromised host and to new integrated diagnostic and therapeutic approaches aimed at defining a personalized treatment for each specific patient.
Finally the microbiota is the main focus in selected patients and apparatuses whereby its presence may influence/be-influenced-by the virulence potential of certain microbes.
The Unit works in tight collaboration with the Microbiology Unit of ASST Niguarda Hospital in Milan, one of the largest microbiology centers in Italy. Both Units are led by Professor Carlo Federico Perno, MD and PhD, who has a major expertise in antimicrobial resistance and antiviral therapy and trained at the National Cancer Institute in Bethesda, US.
The scientific and clinical activities are conducted in collaboration with many excellence Centers in Europe and US, funded by grants of the Italian Government, European Community and private institutions.

Carlo Federico Perno

Graduated from Medical School at the Sapienza University of Rome.
Full Professor of Microbiology at University of Milan and Director of Microbiology and Virology Unit at the ASST Grande Ospedale Metropolitano Niguarda in Milan.

Global Health

The Global Health Centre (Centro di Salute Globale - GHC), a founding component of the new MACH (MultidisciplinAry ResearCh in Health Science) of the University of Milan established with the support of the Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, is the first of its kind in Italy as it merges didactics and research towards “ensuring healthy lives and promoting well-being for all at all ages” (the United Nations’ Sustainable Development Goal 3 target). It aims at becoming a comprehensive and impactful contributor to the global health discussion internationally. The broad vision of the GHC is that of addressing health inequities and improving access to “health for all” through didactic and research activities conducted in partnership with experts from other national and international centres and institutes sharing similar principles and aims in global health. GHC’s ultimate goal is to contribute to the development and implementation across disciplines, in full alignment with the United Nations Sustainable Development Goals (SDGs), of sound health policies and practices that ensure universal access to care and prevention for the most vulnerable people in Italy and the world. To achieve this, multidisciplinary research and education engaging young generations of students that will become future leaders and decisionmakers are essential. The GHC has therefore four essential functions: (1) Training and Education: to create a cadre of future passionate global health leaders capable of being “global health-sensitive” among committed students from different backgrounds, including biomedical sciences, economics, law, international relations, sociology, ecology, agronomy and all other related fields. As part of this programme, at UniMI teaching on the essentials of global health is now integrated as a module into the regular medical student curriculum – a unique situation in Europe – and a new 1-year post-graduate Master Specialty Course in Global Health will start in late 2019 in collaboration with experts from prestigious academic institutions nationally and abroad; (2) Research: to contribute to identification of innovative ways of handling complex public health problems; (3) Health Policy: to focus on evidence generation that influences policy making by health authorities; and (4) Health Promotion and Advocacy: to pursue public awareness and understanding of global health values and healthy behaviours among students and civil society.

Mario Raviglione

Graduated from the University of Turin and specialised in the USA (Cabrini Medical Centre, NY, and Beth Israel Hospital at Harvard Medical School, Boston) in internal medicine, infectious diseases and AIDS. He was director of the Global Tuberculosis Programme at the World Health Organization, Geneva, between 2003 and 2017.
He is Full Professor in Global Health at the University of Milan and holds the appointment of Professeur Titulaire at the Global Studies Institute of the University of Geneva, Switzerland.
Contact: mario.raviglione@unimi.it



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email: mach@unimi.it